Cocaine Cardiotoxicity

@article{Phillips2009CocaineC,
  title={Cocaine Cardiotoxicity},
  author={Katharine R.B. Phillips and Adriana Luk and Gursharan S. Soor and Jonathan R. Abraham and Shaun W. Leong and Jagdish W. Butany},
  journal={American Journal of Cardiovascular Drugs},
  year={2009},
  volume={9},
  pages={177-196}
}
Cocaine is a powerful stimulant that gives users a temporary sense of euphoria, mental alertness, talkativeness, and a decreased need for food and sleep. Cocaine intoxication is the most frequent cause of drug-related death reported by medical examiners in the US, and these events are most often related to the cardiovascular manifestations of the drug. Once playing a vital role in medicine as a local anesthetic, decades of research have established that cocaine has the ability to cause… 

Cocaine and Cardiotoxicity: A Literature Review

A number of small, single-center, retrospective and observational studies suggest that beta-blockers may be safe, effective, and beneficial in this population of patients arriving with cocaine-associated cardiovascular complaints.

Cocaine in acute myocardial infarction.

Cerebrovascular and cardiovascular diseases caused by drugs of abuse

Differential diagnosis is essential because of the likelihood of life-threatening events, especially among young people who exhibit cerebrovascular and cardiovascular diseases without any of the typical risk factors, and careful differential diagnosis and selection of therapeutic agents is required.

Dilated cardiomyopathy secondary to chronic cocaine abuse: a case report

The exact incidence of cocaine related cardiomyopathy is unknown and likely underreported; the clinical course is abrupt and comparatively similar to other types of cardiomeopathy; however β-blockers should be avoided.

Cocaine Cardiac Toxicity: Revisited

Therapy for cocaine induced cardiac toxicity generally includes use of benzo - diazepine agents, nitric oxide mediated vasodilators, alpha blockers and even calcium channel blockers, although Beta blockers are relatively contraindicated in acute settings of cocaine cardiovascular toxicity.

Transient left ventricular acute failure after Cocaine Use.

In critical care unit, Takotsubo cardiomyopathy is a rare complication of cocaine abuse and the treatment does not differ from other causes of cardiopathy and Cessation of cocaine use has been associated with improvement in cardiac function.

Acute and Chronic Effects of Cocaine on Cardiovascular Health

The study found that after cocaine use, populations at high risk for CAD experienced coronary atherosclerosis whereas those at low risk did not experience CAD, suggesting that the chronic effects of cocaine were more likely to be prominent among individuals with higher CAD risk.

Cardiac magnetic resonance in cocaine-induced myocardial damage: cocaine, heart, and magnetic resonance

Cardiac magnetic resonance (CMR) can provide a valuable assessment of cocaine-induced myocardial damage both in acute and chronic cardiac complications: it gives prognostic information in clinically relevant settings, and it identifies silent myocardia damage in asymptomatic patients.
...

References

SHOWING 1-10 OF 175 REFERENCES

Cocaine‐Induced Seizures, Arrhythmias and Sudden Death

Although the pathogenesis of cardiotoxicity of cocaine is not well defined, reported data have associated cocaine use with tachycardia, systemic hypertension, ventricular arrhythmia, acute myocardial infarction, seizures, and sudden death.

Cocaine and Myocardial Infarctions

The cardiovascular complications of cocaine first emerged as a clinical concern in the early to mid-1980s, a period of skyrocketing nontherapeutic cocaine use during which several cocaine-related celebrity deaths were reported.

Cocaine Cardiovascular Toxicity

  • S. Karch
  • Medicine, Biology
    Southern medical journal
  • 2005
Recently it has become clear that genetic causes, such as fully or partially expressed congenital long QT syndrome, may also play a role, and the relative importance of each of these factors is reviewed.

Cardiovascular Effects of Cocaine: Focus on Hypertension.

Though hypertension has been described in the offspring of cocaine using mothers, two recent studies have not found an increased prevalence of chronic hypertension in adults, and long term abuse of cocaine can lead to the various forms of target organ damage usually associated with untreated essential hypertension.

The cardiac cocaine connection.

The pathophysiology of cocaine abuse.

Cocaine and alcohol interactions in humans: neuroendocrine effects and cocaethylene metabolism.

The combination of alcohol and cocaine produced greater increases in HR, rate-pressure product and pleasurable-related subjective effects (euphoria, well-being) compared with the effects of cocaine, and the augmented subjective euphoria may explain why the drug combination is more likely to be abused than is cocaine or alcohol alone.

Cocaine and apoptosis in myocardial cells

Increased oxidative stress and reactive oxygen species, and the subsequent activation of a “stress responsive” enzyme (p38‐mitogen‐activated protein kinase) in theheart may play an important role in cocaine‐induced apoptosis in the heart muscle.
...