Cocaine Blocks Effects of Hunger Hormone, Ghrelin, Via Interaction with Neuronal Sigma-1 Receptors

@article{Aguinaga2018CocaineBE,
  title={Cocaine Blocks Effects of Hunger Hormone, Ghrelin, Via Interaction with Neuronal Sigma-1 Receptors},
  author={David Aguinaga and Mireia Medrano and Arnau Cordom{\'i} and Mireia Jim{\'e}nez-Ros{\'e}s and Edgar Angelats and Mireia Casanovas and Ignacio Vega-Quiroga and Enric I. Canela and Milos M. Petrovic and Katia Gysling and Leonardo Pardo and Rafael Franco and Gemma Navarro},
  journal={Molecular Neurobiology},
  year={2018},
  volume={56},
  pages={1196-1210}
}
Despite ancient knowledge on cocaine appetite-suppressant action, the molecular basis of such fact remains unknown. Addiction/eating disorders (e.g., binge eating, anorexia, bulimia) share a central control involving reward circuits. However, we here show that the sigma-1 receptor (σ1R) mediates cocaine anorectic effects by interacting in neurons with growth/hormone/secretagogue (ghrelin) receptors. Cocaine increases colocalization of σ1R and GHS-R1a at the cell surface. Moreover, in… 
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