Cocaine Blocks Effects of Hunger Hormone, Ghrelin, Via Interaction with Neuronal Sigma-1 Receptors

  title={Cocaine Blocks Effects of Hunger Hormone, Ghrelin, Via Interaction with Neuronal Sigma-1 Receptors},
  author={D. Aguinaga and M. Medrano and A. Cordom{\'i} and Mireia Jim{\'e}nez-Ros{\'e}s and Edgar Angelats and M. Casanovas and I. Vega-Quiroga and E. Canela and M. Petrovic and K. Gysling and L. Pardo and R. Franco and Gemma Navarro},
  journal={Molecular Neurobiology},
Despite ancient knowledge on cocaine appetite-suppressant action, the molecular basis of such fact remains unknown. Addiction/eating disorders (e.g., binge eating, anorexia, bulimia) share a central control involving reward circuits. However, we here show that the sigma-1 receptor (σ1R) mediates cocaine anorectic effects by interacting in neurons with growth/hormone/secretagogue (ghrelin) receptors. Cocaine increases colocalization of σ1R and GHS-R1a at the cell surface. Moreover, in… Expand
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