Cocaine-Associated Stimuli Increase Cocaine Seeking and Activate Accumbens Core Neurons after Abstinence

  title={Cocaine-Associated Stimuli Increase Cocaine Seeking and Activate Accumbens Core Neurons after Abstinence},
  author={Jonathan A. Hollander and R. Carelli},
  journal={The Journal of Neuroscience},
  pages={3535 - 3539}
  • Jonathan A. Hollander, R. Carelli
  • Published 2007
  • Psychology, Medicine
  • The Journal of Neuroscience
  • Electrophysiological recordings were completed in rats (n = 14) trained to self-administer cocaine to determine whether activation of nucleus accumbens (Acb) neurons (core vs shell) by cocaine-associated stimuli is enhanced after 1 month of cocaine abstinence. After self-administration training, 170 cells were recorded during a single test session conducted either the next day or 1 month later. The test session consisted of three phases during which (1) the cocaine cue was presented… CONTINUE READING
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