Cocaine Activation Discriminates Dopaminergic Projections by Temporal Response: An fMRI Study in Rat

@article{Marota2000CocaineAD,
  title={Cocaine Activation Discriminates Dopaminergic Projections by Temporal Response: An fMRI Study in Rat},
  author={John J. A. Marota and Joseph B. Mandeville and Robert M. Weisskoff and Michael A. Moskowitz and B. Kosofsky},
  journal={NeuroImage},
  year={2000},
  volume={11},
  pages={13-23}
}
We applied a sensitive new functional magnetic resonance imaging technique to identify the pattern and determinants of cocaine-induced brain activation in drug-naive rats. At doses greater than 0.1 mg/kg iv, cocaine produced robust activation throughout cortex with the largest magnitude increase in frontal neocortex. Additionally, we detected selective activation within dopamine-innervated subcortical regions including dorsomedial and ventrolateral striatum, nucleus accumbens region, and dorsal… CONTINUE READING
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