Corpus ID: 37129800

Cocaine Abuse and Reproductive Function in Women

@inproceedings{Mello1998CocaineAA,
  title={Cocaine Abuse and Reproductive Function in Women},
  author={Nancy K. Mello},
  year={1998}
}

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References

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Cocaine’s Effects on Neuroendocrine Systems: Clinical and Preclinical Studies
TLDR
This review examines the effects of cocaine on the neuroendocrine system and summarizes findings from clinical studies of cocaine abusers and preclinical studies in rodents and rhesus monkeys, revealing disruptions of the estrous cycle in rats and the menstrual cycle in rhesUS monkeys. Expand
Gender differences in cerebral perfusion in cocaine abuse: technetium-99m-HMPAO SPECT study of drug-abusing women.
TLDR
It is suggested that cocaine-dependent women have fewer abnormalities in cerebral perfusion than cocaine- dependent men, but that concurrent abuse of heroin and cocaine is associated with more perfusion abnormalities in both sexes. Expand
Effects of dopamine on prolactin: interactions with cocaine self-administration by female rhesus monkeys.
TLDR
The data suggest that the prolactin secretory response to dopamine perturbation may provide a sensitive index of changes in dopaminergic regulation of prolact in female rhesus monkeys during chronic cocaine exposure. Expand
A primate model of polydrug abuse: cocaine and heroin combinations.
TLDR
The feasibility of maintaining self-administration of cocaine-heroin combinations is demonstrated and it is suggested that cocaine and heroin have similar reinforcing and discriminative stimulus effects in rhesus monkeys. Expand
The acute effects of cocaine on anterior pituitary hormones in ovariectomized rhesus monkeys.
TLDR
Cocaine did not significantly increase the magnitude or duration of LHRH-stimulated increases in gonadotropins in ovariectomized females as it did in follicular phase females and in early follicular and midluteal phase rhesus females. Expand
Acute effects of cocaine on anterior pituitary hormones in male and female rhesus monkeys.
TLDR
The effects of acute cocaine administration on anterior pituitary hormones were studied in four male and six female adult rhesus monkeys during the midluteal phase of the menstrual cycle and found that cocaine increased LH and enhanced luteinizing hormone-releasing hormone-stimulated LH in early follicular females. Expand
Acute effects of cocaine on plasma adrenocorticotropic hormone, luteinizing hormone and prolactin levels in cocaine-dependent men.
TLDR
Cocaine-induced increases in plasma ACTH levels may be due to its effects on dopaminergic systems which modulate corticotropin-releasing factor release in brain. Expand
Buprenorphine attenuates the effects of cocaine on adrenocorticotropin (ACTH) secretion and mood states in man.
TLDR
An opioid mixed agonist-antagonist, buprenorphine, suppressed the acute cocaine-induced stimulation of both ACTH and euphoria, which paralleled increases in plasma cocaine levels and self-reports of salient drug effects on mood states. Expand
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Acute effects of cocaine on prolactin and gonadotropins in female rhesus monkey during the follicular phase of the menstrual cycle.
TLDR
The acute effects of i.v. cocaine on basal levels of prolactin (PRL), luteinizing hormone (LH) and follicle-stimulating hormone were examined in nine female rhesus monkeys during the early follicular phase of the menstrual cycle and cocaine's stimulation of LH is consistent with cocaine's alleged enhancement of sexual arousal. Expand
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