Cocaethylene is more potent than cocaine in mediating lethality

@article{Hearn1991CocaethyleneIM,
  title={Cocaethylene is more potent than cocaine in mediating lethality},
  author={W. Hearn and S. Rose and J. Wagner and A. Ciarleglio and D. Mash},
  journal={Pharmacology Biochemistry and Behavior},
  year={1991},
  volume={39},
  pages={531-533}
}
Cocaethylene is a pharmacologically active cocaine metabolite that is formed in the presence of ethanol by the activity of liver enzymes. The pharmacology of cocaethylene has not been extensively investigated and its acute toxicity is unknown. The acute toxicity of cocaethylene was compared to cocaine in Swiss-Webster mice. The LD50 of cocaethylene was 60.7 mg/kg and 63.8 mg/kg in female and male mice, respectively. In comparison, the LD50 of cocaine was 93.0 mg/kg in both female and male mice… Expand
Subjective and cardiovascular effects of cocaethylene in humans
Premorbid behaviors produced by cocaine, ethanol and cocaethylene in the mouse.
Assessment of cocaethylene lethality in Long-Evans female and male rats.
Cocaine, ethanol, and cocaethylene cardiotoxity in an animal model of cocaine and ethanol abuse.
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References

SHOWING 1-10 OF 11 REFERENCES
Comparative lethality of coca and cocaine
Cocaethylene: A Unique Cocaine Metabolite Displays High Affinity for the Dopamine Transporter
Cocaine inhibits muscarinic cholinergic receptors in heart and brain.
Cardiovascular effects of cocaine: enhancement by yohimbine and atropine.
  • R. Wilkerson
  • Medicine
  • The Journal of pharmacology and experimental therapeutics
  • 1989
A simplified method of evaluating dose-effect experiments.
Do we know the lethal dose of cocaine?
Alcoholism and polydrug use: the need for the "basics".
...
1
2
...