Cocaethylene: a neuropharmacologically active metabolite associated with concurrent cocaine-ethanol ingestion.

@article{Jatlow1991CocaethyleneAN,
  title={Cocaethylene: a neuropharmacologically active metabolite associated with concurrent cocaine-ethanol ingestion.},
  author={Peter I. Jatlow and John D. Elsworth and Charles W. Bradberry and Gail D. Winger and Jane Rebecca Taylor and R Patterson Russell and Robert H. Roth},
  journal={Life sciences},
  year={1991},
  volume={48 18},
  pages={
          1787-94
        }
}
High concentrations of cocaethylene (EC), the ethyl ester of benzoylecgonine, were measured in the blood of individuals who had concurrently used cocaine and ethanol. Since the powerful reinforcing effects of cocaine appear to be dependent on inhibition of dopamine reuptake in brain, we compared the effects of EC on the dopamine uptake system and its behavioral effects with those of cocaine. EC was equipotent to cocaine with respect to inhibition of binding of [3H]GBR 12935 to the dopamine… CONTINUE READING

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