Cobrotoxin inhibits NF-kappa B activation and target gene expression through reaction with NF-kappa B signal molecules.

@article{Park2005CobrotoxinIN,
  title={Cobrotoxin inhibits NF-kappa B activation and target gene expression through reaction with NF-kappa B signal molecules.},
  author={Mi Park and Ho Seub Song and Ki Hyun Kim and Dong Ju Son and Seung Ho Lee and Do-Young Yoon and Youngsoo Kim and Il Young Park and Sukgil Song and Bang Yeon Hwang and Jae Kyung Jung and Jin Tae Hong},
  journal={Biochemistry},
  year={2005},
  volume={44 23},
  pages={8326-36}
}
Cobrotoxin is known to bind with cysteine residues of biological molecules such as nicotine acetylcholine receptor. Cobrotoxin may modify IKKs and p50 through protein-protein interaction since cysteine residues are present in the kinase domains of IKKalpha and IKKbeta and in the p50 of NF-kappaB. Our surface plasmon resonance analysis showed that cobrotoxin directly binds to p50 (K(d) = 1.54 x 10(-)(5) M), IKKalpha (K(d) = 3.94 x 10(-)(9) M) and IKKbeta (K(d) = 3.4 x 10(-)(8) M) with high… CONTINUE READING

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