Cobicistat boosts the intestinal absorption of transport substrates, including HIV protease inhibitors and GS-7340, in vitro.

@article{Lepist2012CobicistatBT,
  title={Cobicistat boosts the intestinal absorption of transport substrates, including HIV protease inhibitors and GS-7340, in vitro.},
  author={Eve-Irene Lepist and Truc K Phan and Anupma Roy and Leah Tong and Kelly Maclennan and Bernard P Murray and Adrian S Ray},
  journal={Antimicrobial agents and chemotherapy},
  year={2012},
  volume={56 10},
  pages={5409-13}
}
The experimental pharmacoenhancer cobicistat (COBI), a potent mechanism-based inhibitor of cytochrome P450 3A enzymes, was found to inhibit the intestinal efflux transporters P-glycoprotein and breast cancer resistance protein. Consistent with its transporter inhibition, COBI significantly increased the absorptive flux of potential candidates for clinical coadministration, including the HIV protease inhibitors atazanavir and darunavir and the lymphoid cell- and tissue-targeted prodrug of the… CONTINUE READING

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