Cobalt versus Osmium: Control of Both trans and cis Selectivity in Construction of the EFG Rings of Pectenotoxin 4.

@article{Roushanbakhti2017CobaltVO,
  title={Cobalt versus Osmium: Control of Both trans and cis Selectivity in Construction of the EFG Rings of Pectenotoxin 4.},
  author={Ahria Roushanbakhti and Yifan Liu and Paul C M Winship and Michael J Tucker and Wasim M Akhtar and Daryl S. Walter and Gail Wrigley and Timothy J Donohoe},
  journal={Angewandte Chemie},
  year={2017},
  volume={56 47},
  pages={14883-14887}
}
Catalytic oxidative cyclisation reactions have been employed for the synthesis of the E and F rings of the complex natural product target pectenotoxin 4. The choice of metal catalyst (cobalt- or osmium-based) allowed for the formation of THF rings with either trans or cis stereoselectivity. Fragment union using a modified Julia reaction then enabled the synthesis of an advanced synthetic intermediate containing the EF and G rings of the target. 
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