Cobalt pellets and Heliotropium europaeum poisoning in penned sheep.

@article{Lanigan1970CobaltPA,
  title={Cobalt pellets and Heliotropium europaeum poisoning in penned sheep.},
  author={G. W. Lanigan and J. H. Whittem},
  journal={Australian veterinary journal},
  year={1970},
  volume={46 1},
  pages={
          17-21
        }
}
Summary Twenty-five sheep in single pens were fed for up to 16 months a ration containing up to 40% (air dry weight basis) of Heliotropium europaeum. Thirteen of these sheep had two cobalt pellets administered into their rumen before commencement of feeding. The other twelve sheep constituted the control group and were not treated in any way. The sheep in both groups developed the characteristic live pathology of chronic pyrrolizidine alkaloidosis to varying degrees. The… 
Antimethanogenic drugs and Heliotropium europaeum poisoning in penned sheep
TLDR
iodoform prophylaxis may be a useful protective measure in the field for sheep exposed to H. europaeum grazing during a single season and indicates that there are prospects for development of a pyrrolizidine-tolerant strain of sheep by selective breeding.
Heliotropium europaeum poisoning of sheep with low liver copper concentrations and the preventive efficacy of cobalt and antimethanogen.
TLDR
The relatively low mortality from primary heliotrope poisoning and the low concentration of copper in the liver of sheep grazing the plant are discussed in relation to the contrasting situation that prevails in the Riverina area of New South Wales.
Seasonal dynamics in the pyrrolizidine alkaloids of Heliotropium europaeum
TLDR
Correlation of rainfall and average number of leaves per plant with lasiocarpine and europine levels suggested that rainfall, either directly by altering the metabolism of existing leaves or indirectly through plant growth, initiated large short-term shifts in PA composition of H. europaeum.
PYRROLIZIDINE ALKALOID POISONING - PATHOLOGY WITH PARTICULAR REFERENCE TO DIFFERENCES IN ANIMAL AND PLANT SPECIES
TLDR
Pigs were quantitatively the most sensitive of the animals studied, then chickens, cattle, horses, rats, and mice; sheep and goats were the most resistant; sheep were resistant to the chronic effects, they were quite sensitive to acute poisonings.
PREVENTION OF PYRROLIZIDINE ALKALOID POISONING–ANIMAL ADAPTATION OR PLANT CONTROL?
TLDR
Investigations into the protection of sheep from poisoning by Heliotropium europaeum are summarized and 6-Succinyloxysenecionine conjugates, designed to induce antibodies forming irreversible complexes, are under test.
PHARMACOLOGICAL AND TOXICOLOGICAL EFFECTS OF HELIOTROPIUM UNDULATUM [H. BACCIFERUM] AND HELIOTROPIUM EUROPAEUM- A REVIEW
TLDR
The phytochemical analysis of Heliotropium undulatum revealed the presence of alkaloids, saponins, tannins, steroids, terpenoids, flavonoids, glycosides, and phenols, which showed that these species possessed antioxidant, antimicrobial, anti-inflammatory and hapatoprotective effects.