Cobalt ions influence proliferation and function of human osteoblast-like cells.

@article{Anissian2002CobaltII,
  title={Cobalt ions influence proliferation and function of human osteoblast-like cells.},
  author={Lucas Anissian and Andr{\'e} Stark and Henrik Dahlstrand and Barbro Granberg and Victoria Good and Elisabet Bucht},
  journal={Acta orthopaedica Scandinavica},
  year={2002},
  volume={73 3},
  pages={369-74}
}
Cobalt is the major component in many orthopedic implants and the introduction of a second generation of metal on metal bearing prosthesis systems actualizes the toxicity and biocompatibility of this compound. We studied the effect of cobalt ions on primary cultures of human osteoblast-like cells. Cobalt ions dissolved in cell culture medium caused a dose-dependent decrease in proliferation of human osteoblasts measured as (3H)thymidine incorporation. We also found that cobalt ion-enriched… CONTINUE READING

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