Cobalt induces oxidative stress in isolated liver mitochondria responsible for permeability transition and intrinsic apoptosis in hepatocyte primary cultures.

@article{Battaglia2009CobaltIO,
  title={Cobalt induces oxidative stress in isolated liver mitochondria responsible for permeability transition and intrinsic apoptosis in hepatocyte primary cultures.},
  author={Valentina Battaglia and Alessandra Compagnone and Andrea Bandino and Marcantonio Bragadin and Carlo Alberto Rossi and Filippo Zanetti and Sebastiano Colombatto and Maria Angelica Grillo and Antonio Toninello},
  journal={The international journal of biochemistry & cell biology},
  year={2009},
  volume={41 3},
  pages={586-94}
}
It is well established that cobalt mediates the occurrence of oxidative stress which contributes to cell toxicity and death. However, the mechanisms of these effects are not fully understood. This investigation aimed at establishing if cobalt acts as an inducer of mitochondrial-mediated apoptosis and at clarifying the mechanism of this process. Cobalt, in the ionized species Co(2+), is able to induce the phenomenon of mitochondrial permeability transition (MPT) in rat liver mitochondria (RLM… CONTINUE READING