Cobalt chloride-induced apoptosis and extracellular signal-regulated protein kinase activation in human cervical cancer HeLa cells.

@article{Kim2003CobaltCA,
  title={Cobalt chloride-induced apoptosis and extracellular signal-regulated protein kinase activation in human cervical cancer HeLa cells.},
  author={Hyun Jeong Kim and Seung-ju Yang and Yoon Suk Kim and Tae Ue Kim},
  journal={Journal of biochemistry and molecular biology},
  year={2003},
  volume={36 5},
  pages={
          468-74
        }
}
The molecular mechanism of hypoxia-induced apoptosis has not been clearly elucidated. In this study, we investigated the involvement of extracellular signal-regulated protein kinase (ERK 1/2) in hypoxia-induced apoptosis using cobalt chloride in HeLa human cervical cancer cells. The cobalt chloride was used for the induction of hypoxia, and its IC(50) was 471.4 microM. We demonstrated the DNA fragmentation after incubation with concentrations more than 50 microM cobalt chloride for 24 h, and… CONTINUE READING