Cobalt-Catalyzed Enantioselective Vinylation of Activated Ketones and Imines.

Abstract

We present here an unprecedented cobalt-catalyzed enantioselective vinylation of α-ketoesters, isatins, and imines to deliver a range of synthetically useful allylic alcohols and amines in high enantiopurity. This method employs commercially available and easy to handle catalysts and reagents and exhibits a high degree of practicality. The efficiency… (More)
DOI: 10.1021/jacs.6b02372

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Cite this paper

@article{Huang2016CobaltCatalyzedEV, title={Cobalt-Catalyzed Enantioselective Vinylation of Activated Ketones and Imines.}, author={Yuan Huang and Rui-Zhi Huang and Yu Zhao}, journal={Journal of the American Chemical Society}, year={2016}, volume={138 20}, pages={6571-6} }