Cobalamin-folate interrelations: a critical review.

@article{Chanarin1985CobalaminfolateIA,
  title={Cobalamin-folate interrelations: a critical review.},
  author={I. Chanarin and Rob Deacon and Michael J. Lumb and Mary Muir and Janet Perry},
  journal={Blood},
  year={1985},
  volume={66 3},
  pages={
          479-89
        }
}
. cobalamin . + homocysteine p H4PteGlu + methionine. In the absence of cobalamin the reaction is impaired, the methyl group remains on tetrahydrofolate (H4PteGlu), and a critical lack of free tetrahydrofolate develops. As a result, single-carbon units such as formate and methylene cannot be taken up because of lack of a folate acceptor and synthesis of purines requiring formate, and that of thymidine requiring methylene, is impaired. The thermodynamics of the reaction by which methylfolate is… CONTINUE READING

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