Cobalamin deficiency results in an abnormal increase in L-methylmalonyl-co-enzyme-A mutase expression in rat liver and COS-7 cells.

@article{Nakao2008CobalaminDR,
  title={Cobalamin deficiency results in an abnormal increase in L-methylmalonyl-co-enzyme-A mutase expression in rat liver and COS-7 cells.},
  author={Motoyuki Nakao and Shoko Hironaka and Naoki Harada and Tetsuya Adachi and Tomohiro Bito and Yukinori Yabuta and Fumio Watanabe and Takumi Miura and Ryoichi Yamaji and Hiroshi Inui and Yoshihisa Nakano},
  journal={The British journal of nutrition},
  year={2008},
  volume={101 4},
  pages={
          492-8
        }
}
The aim of the present study was to examine the effects of cobalamin (Cbl) on the activity and expression of L-methylmalonyl-CoA mutase (MCM) in rat liver and cultured COS-7 cells. The MCM holoenzyme activity was less than 5% of the total (holoenzyme+apoenzyme) activity in the liver although rats were fed a diet containing sufficient Cbl. When weanling rats were maintained on a Cbl-deficient diet, the holo-MCM activity became almost undetectable at the age of 10 weeks. In contrast, a marked… CONTINUE READING

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