Cobalamin (vitamin B12) biosynthesis: identification and characterization of a Bacillus megaterium cobI operon.

@article{Raux1998CobalaminB,
  title={Cobalamin (vitamin B12) biosynthesis: identification and characterization of a Bacillus megaterium cobI operon.},
  author={Evelyne Raux and Anne Lanois and Martin J. Warren and Alain Rambach and Claude Thermes},
  journal={The Biochemical journal},
  year={1998},
  volume={335 ( Pt 1)},
  pages={159-66}
}
A 16 kb DNA fragment has been isolated from a Bacillus megaterium genomic library and fully sequenced. The fragment contains 15 open reading frames, 14 of which are thought to constitute a B. megaterium cobalamin biosynthetic (cob) operon. Within the operon, 11 genes display similarity to previously identified Salmonella typhimurium cobalamin biosynthetic genes (cbiH60, -J, -C, -D, -ET, -L, -F, -G, -A, cysGA and btuR), whereas three do not (cbiW, -X and -Y). The genes of the B. megaterium cob… CONTINUE READING
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