Cobalamin (vitamin B(12)) positively regulates interleukin-6 levels in rat cerebrospinal fluid.

@article{Scalabrino2002CobalaminB,
  title={Cobalamin (vitamin B(12)) positively regulates interleukin-6 levels in rat cerebrospinal fluid.},
  author={Giuseppe Scalabrino and Massimiliano Marco Corsi and Daniela Veber and Francesca R Buccellato and Giulio Pravettoni and Alfredo Manfridi and Paolo Magni},
  journal={Journal of neuroimmunology},
  year={2002},
  volume={127 1-2},
  pages={37-43}
}
We have previously demonstrated that the repeated intracerebroventricular (i.c.v.) microinjection of interleukin-6 (IL-6) prevented the myelinolytic lesions of cobalamin-deficient (Cbl-D) central neuropathy [or subacute combined degeneration (SCD)] in totally gastrectomized (TGX) rats. We therefore hypothesized that cobalamin (Cbl) may actually regulate IL-6 levels in rat cerebrospinal fluid (CSF). We measured IL-6 levels in the CSF of rats made Cbl-D by means of total gastrectomy (TG) or… CONTINUE READING

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