Twenty patients with headaches and concomitant mild depression (the Beck scale mean score 13,6), aged 20-62 years (mean 40,3), illness duration 0,5-40 years, (mean 17,7), attack frequency 3-30 days, (mean 13,4), have been studied. Coaxil was prescribed in dosage of 12,5 mg daily during 6 weeks. Neurological examination and clinical evaluation using a number of scales, along with patients self-rating, was conducted. Twenty one patients have completed the treatment course. Coaxil therapy resulted in significant decrease of frequency and severity of headache attacks and improvement of the patient's general state.