Coating of pharmaceutical powders by fluidized bed process. II. Microcapsules produced by layering of fine powder on coarse particles and subsequent aqueous enteric coating.

@article{Fukumori1988CoatingOP,
  title={Coating of pharmaceutical powders by fluidized bed process. II. Microcapsules produced by layering of fine powder on coarse particles and subsequent aqueous enteric coating.},
  author={Yoshinobu Fukumori and Yumiko Yamaoka and Hideki Ichikawa and Tomoaki Fukuda and Yoshikazu Takeuchi and Yoshifumi Osako},
  journal={Chemical \& pharmaceutical bulletin},
  year={1988},
  volume={36 4},
  pages={
          1491-501
        }
}
The Wurster process (Glatt GPCG-1) could produce particles whose outer layer consisted of fine phenacetin particles (70% under 20μm) adhering to or fixed on lactose particles (90μm), when a mixture of both powders was fluidized and sprayed with a binder solution. The enteric coating of layered particles was performed with an aqueous methacrylic acid-ethylacrylate (MA-EA) copolymer suspension (Eudragit L30D-55).The simple MA-EA microcapsules of coarse lactose crystals (120μm) exhibited a delayed… 
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