Coating of pharmaceutical powders by fluidized bed process. I. Aqueous enteric coating with methacrylic acid-ethylacrylate copolymer and the dissolution behavior of products.

@article{Fukumori1987CoatingOP,
  title={Coating of pharmaceutical powders by fluidized bed process. I. Aqueous enteric coating with methacrylic acid-ethylacrylate copolymer and the dissolution behavior of products.},
  author={Yoshinobu Fukumori and Tomoaki Fukuda and Y Hanyu and Yoshikazu Takeuchi and Yoshifumi Osako},
  journal={Chemical \& pharmaceutical bulletin},
  year={1987},
  volume={35 7},
  pages={
          2949-57
        }
}
Phenacetin and lactose powders, as models of slightly and highly water-soluble drugs, respectively, were coated by means of the Wurster process.Phenacetin (80-250 mesh) was a fragile crystalline material and hence fluidization had to be moderate. As a result, the agglomeration of some particles or the adhesion of small particles to large particles could not be avoided. However, the particles coated with triacetin (plasticizer) -containing lacquer (60% as dry lacquer relative to the core… 

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