Coat proteins and vesicle budding.

  title={Coat proteins and vesicle budding.},
  author={Randy Schekman and Lelio Orci},
  volume={271 5255},
The trafficking of proteins within eukaryotic cells is achieved by the capture of cargo and targeting molecules into vesicles that bud from a donor membrane and deliver their contents to a receiving department. This process is bidirectional and may involve multiple organelles within a cell. Distinct coat proteins mediate each budding event, serving both to shape the transport vesicle and to select by direct or indirect interaction the desired set of cargo molecules. Secretion, which has been… CONTINUE READING