Corpus ID: 27399725

Coassembly of K(V)LQT1 and minK (IsK) proteins to form cardiac I(Ks) potassium channel.

@article{Sanguinetti1996CoassemblyOK,
  title={Coassembly of K(V)LQT1 and minK (IsK) proteins to form cardiac I(Ks) potassium channel.},
  author={M. Sanguinetti and M. Curran and A. Zou and J. Shen and P. Spector and D. Atkinson and M. Keating},
  journal={Nature},
  year={1996},
  volume={384 6604},
  pages={
          80-3
        }
}
The slowly activating delayed-rectifier K+ current, I(Ks), modulates the repolarization of cardiac action potentials. The molecular structure of the I(Ks) channel is not known, but physiological data indicate that one component of the I(Ks), channel is minK, a 130-amino-acid protein with a single putative transmembrane domain. The size and structure of this protein is such that it is unlikely that minK alone forms functional channels. We have previously used positional cloning techniques to… Expand
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