Coarse-grained simulation reveals key features of HIV-1 capsid self-assembly.

@article{Grime2016CoarsegrainedSR,
  title={Coarse-grained simulation reveals key features of HIV-1 capsid self-assembly.},
  author={John M A Grime and James F Dama and Barbie K Ganser-Pornillos and Cora L. Woodward and Grant J. Jensen and Mark Yeager and Gregory A. Voth},
  journal={Nature communications},
  year={2016},
  volume={7},
  pages={
          11568
        }
}
The maturation of HIV-1 viral particles is essential for viral infectivity. During maturation, many copies of the capsid protein (CA) self-assemble into a capsid shell to enclose the viral RNA. The mechanistic details of the initiation and early stages of capsid assembly remain to be delineated. We present coarse-grained simulations of capsid assembly under various conditions, considering not only capsid lattice self-assembly but also the potential disassembly of capsid upon delivery to the… CONTINUE READING
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Modeling Viral Capsid Assembly.

Advances in chemical physics • 2014

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