Coarse-grained simulation reveals key features of HIV-1 capsid self-assembly.

  title={Coarse-grained simulation reveals key features of HIV-1 capsid self-assembly.},
  author={John M A Grime and James F Dama and Barbie K Ganser-Pornillos and Cora L. Woodward and Grant J. Jensen and Mark Yeager and Gregory A. Voth},
  journal={Nature communications},
The maturation of HIV-1 viral particles is essential for viral infectivity. During maturation, many copies of the capsid protein (CA) self-assemble into a capsid shell to enclose the viral RNA. The mechanistic details of the initiation and early stages of capsid assembly remain to be delineated. We present coarse-grained simulations of capsid assembly under various conditions, considering not only capsid lattice self-assembly but also the potential disassembly of capsid upon delivery to the… CONTINUE READING
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