• Corpus ID: 16773869

Coarse-grained modelling of strong DNA bending I: Thermodynamics and comparison to an experimental "molecular vice"

@article{Harrison2015CoarsegrainedMO,
  title={Coarse-grained modelling of strong DNA bending I: Thermodynamics and comparison to an experimental "molecular vice"},
  author={Ryan M. Harrison and Flavio Romano and Thomas E. Ouldridge and Ard A. Louis and Jonathan P. K. Doye},
  journal={arXiv: Biomolecules},
  year={2015}
}
DNA bending is biologically important for genome regulation and is relevant to a range of nanotechnological systems. Recent results suggest that sharp bending is much easier than implied by the widely-used worm-like chain model; many of these studies, however, remain controversial. We use a coarse-grained model, previously fitted to DNA's basic thermodynamic and mechanical properties, to explore strongly bent systems. We find that as the end-to-end distance is decreased sufficiently short… 

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