Coarse-grained modeling of allosteric regulation in protein receptors.

Abstract

Allosteric regulation provides highly specific ligand recognition and signaling by transmembrane protein receptors. Unlike functions of protein molecular machines that rely on large-scale conformational transitions, signal transduction in receptors appears to be mediated by more subtle structural motions that are difficult to identify. We describe a… (More)
DOI: 10.1073/pnas.0901811106

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