Coarse-Grained Potentials for Local Interactions in Unfolded Proteins.

  title={Coarse-Grained Potentials for Local Interactions in Unfolded Proteins.},
  author={Ali Ghavami and Erik van der Giessen and P. R. Onck},
  journal={Journal of chemical theory and computation},
  volume={9 1},
Recent studies have revealed the key role of natively unfolded proteins in many important biological processes. In order to study the conformational changes of these proteins, a one-bead-per-amino-acid coarse grained (CG) model is developed, and a method is proposed to extract the potential functions for the local interactions between CG beads. Experimentally obtained Ramachandran data for the coil regions of proteins are converted into distributions of pseudo-bond and pseudo-dihedral angles… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 1 time over the past 90 days. VIEW TWEETS