Coapplication of lidocaine and the permanently charged sodium channel blocker QX-314 produces a long-lasting nociceptive blockade in rodents.

@article{Binshtok2009CoapplicationOL,
  title={Coapplication of lidocaine and the permanently charged sodium channel blocker QX-314 produces a long-lasting nociceptive blockade in rodents.},
  author={Alexander M. Binshtok and Peter Gerner and Seog Bae Oh and Michelino Puopolo and Suzuko Suzuki and David P. Roberson and Teri A Herbert and Chi-Fei Wang and Donghoon Kim and Gehoon Chung and Aya A. Mitani and G. K. Wang and Bruce P. Bean and Clifford J Woolf},
  journal={Anesthesiology},
  year={2009},
  volume={111 1},
  pages={127-37}
}
BACKGROUND Nociceptive-selective local anesthesia is produced by entry of the permanently charged lidocaine-derivative QX-314 into nociceptors when coadministered with capsaicin, a transient receptor potential vanilloid 1 (TRPV1) channel agonist. However, the pain evoked by capsaicin before establishment of the QX-314-mediated block would limit clinical utility. Because TRPV1 channels are also activated by lidocaine, the authors tested whether lidocaine can substitute for capsaicin to introduce… CONTINUE READING
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Permeation and block of TRPV1 channels by cationic local anesthetics (abstract)

  • M Puopolo, AM Binshtok, CJ Woolf, BP Bean
  • Society for Neuroscience
  • 2008

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