Coantioxidants make alpha-tocopherol an efficient antioxidant for low-density lipoprotein.

  title={Coantioxidants make alpha-tocopherol an efficient antioxidant for low-density lipoprotein.},
  author={Shane Ross Thomas and Jiri Neuzil and Donna Mohr and Roland Stocker},
  journal={The American journal of clinical nutrition},
  volume={62 6 Suppl},
The oxidation of low-density lipoproteins (LDLs) is now commonly implicated as an important early event in atherogenesis. The resulting interest in LDL antioxidation has focused on alpha-tocopherol, the biologically and chemically most active form of vitamin E and quantitatively the major lipid-soluble antioxidant in extracts prepared from human LDL. We review advances made in our understanding of the molecular action of alpha-tocopherol in radical-mediated oxidation of isolated human LDL and… CONTINUE READING

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