Coalterations of p53 and PTEN tumor suppressor genes in non-small cell lung carcinoma patients.

@article{Andjelkovi2011CoalterationsOP,
  title={Coalterations of p53 and PTEN tumor suppressor genes in non-small cell lung carcinoma patients.},
  author={Tijana Andjelkovi{\'c} and Jasna Bankovi{\'c} and Jelena M Stojsi{\'c} and Vedrana P. Milinkovi{\'c} and Ana Podolski-Reni{\'c} and Sabera D Ruzdiji{\'c} and Nikola T. Tani{\'c}},
  journal={Translational research : the journal of laboratory and clinical medicine},
  year={2011},
  volume={157 1},
  pages={19-28}
}
The inactivation of p53 and PTEN tumor suppressor genes is a common genetic event in lung cancer. However, data on the effect of the joint inactivation of tumor-suppressor genes in non-small cell lung carcinoma (NSCLC) are lacking. The purpose of this study was to investigate the alterations in PTEN and p53 genes, as well as to evaluate their mutual role in NSCLC pathogenesis and their impact on survival rate. To that end, polymerase chain reaction single-strand conformational polymorphism (PCR… CONTINUE READING