Coalescence of phospholipid membranes as a possible origin of anticoagulant effect of serum proteins.

@article{Urbanija2007CoalescenceOP,
  title={Coalescence of phospholipid membranes as a possible origin of anticoagulant effect of serum proteins.},
  author={Jasna Urbanija and Nejc Tom{\vs}i{\vc} and Maru{\vs}a Lokar and Ale{\vs} Ambro{\vz}i{\vc} and Sa{\vs}a {\vC}u{\vc}nik and Bla{\vz} Rozman and Ma{\vs}a Kandu{\vs}er and Ales Iglic and Veronika Kralj-Igli{\vc}},
  journal={Chemistry and physics of lipids},
  year={2007},
  volume={150 1},
  pages={49-57}
}
Interactions between phospholipid membranes (made of palmitoyloleoylphosphatidylcholine, cardiolipin and cholesterol) after addition of beta2 glycoprotein I (beta2GPI) or anti-beta2GPI antibodies or a mixture of both were studied by observing giant phospholipid vesicles under the phase contrast microscope. Both, negatively charged and neutral vesicles coalesced into complexes and adhered to the bottom of the observation chamber in the presence of beta2GPI in solution. Anti-beta2GPIs alone or… CONTINUE READING