Coagulation on biomaterials in flowing blood: some theoretical considerations.

@article{Basmadjian1997CoagulationOB,
  title={Coagulation on biomaterials in flowing blood: some theoretical considerations.},
  author={Diran Basmadjian and Michael Vivian Sefton and Susan Anne Baldwin},
  journal={Biomaterials},
  year={1997},
  volume={18 23},
  pages={1511-22}
}
Are truly inert biomaterials feasible? Recent mathematical models of coagulation which are reviewed here suggest that such materials are impossible. This conclusion, which is certainly consistent with our collective experimental evidence, arises from the calculation that conversion of Factor XI to XIa never drops to zero even at the highest flow rates and with virtually no Factor XIIa bound to a surface. Residual amounts of XIa are still formed which can in principle kick-off the coagulation… CONTINUE READING

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