Coagulation initiated on herpesviruses.

  title={Coagulation initiated on herpesviruses.},
  author={Michael Reed Sutherland and C M Raynor and H Leenknegt and Jill F. Wright and Edward L. G. Pryzdial},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={94 25},
Herpesviruses have been previously correlated to vascular disease and shown to cause thrombogenic and atherogenic changes to host cells. Herein we show that even in the absence of cells, purified cytomegalovirus (CMV) and herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) can initiate thrombin production. Functional assays demonstrated that purified HSV-1 and HSV-2 provide the necessary phospholipid (proPL) for assembling the coagulation factors Xa and Va into prothrombinase, which is… CONTINUE READING
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