Coagulation inhibitor substitution during sepsis

@article{Fourrier2005CoagulationIS,
  title={Coagulation inhibitor substitution during sepsis},
  author={F. Fourrier and M. Jourdain and A. Tournois and C. Caron and J. Goudemand and C. Chopin},
  journal={Intensive Care Medicine},
  year={2005},
  volume={21},
  pages={S264-S268}
}
  • F. Fourrier, M. Jourdain, +3 authors C. Chopin
  • Published 2005
  • Medicine
  • Intensive Care Medicine
  • This review presents the rationale for and main results of coagulation inhibitor substitution during experimental and human sepsis. Activation of the contact system induces activation of the classical complement pathway with generation of anaphylatoxins, of the kinins pathway and of fibrinolysis. Physiologic inhibition depends on the C1-inhibitor (C1-Inh.). Septic patients exhibit a relative deficiency of biologically active C1-Inh. Substitution with concentrations of C1-Inh has been safely… CONTINUE READING
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    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 39 REFERENCES
    Elevated plasma levels of the anaphylatoxins C3a and C4a are associated with a fatal outcome in sepsis.
    • 195