Coagulation inhibitor substitution during sepsis

  title={Coagulation inhibitor substitution during sepsis},
  author={François Fourrier and Merc{\'e} Jourdain and A. Tournois and Christine Caron and Jenny Goudemand and Claude Chopin},
  journal={Intensive Care Medicine},
This review presents the rationale for and main results of coagulation inhibitor substitution during experimental and human sepsis. Activation of the contact system induces activation of the classical complement pathway with generation of anaphylatoxins, of the kinins pathway and of fibrinolysis. Physiologic inhibition depends on the C1-inhibitor (C1-Inh.). Septic patients exhibit a relative deficiency of biologically active C1-Inh. Substitution with concentrations of C1-Inh has been safely… CONTINUE READING


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