Coagulation induced by C3aR-dependent NETosis drives protumorigenic neutrophils during small intestinal tumorigenesis.

@article{Guglietta2016CoagulationIB,
  title={Coagulation induced by C3aR-dependent NETosis drives protumorigenic neutrophils during small intestinal tumorigenesis.},
  author={Silvia Guglietta and Andrea Chiavelli and Elena Zagato and Carsten Krieg and Sara Gandini and Paola Simona Ravenda and Barbara Bazolli and Bao Shi Lu and Giuseppe Penna and Maria Rescigno},
  journal={Nature communications},
  year={2016},
  volume={7},
  pages={11037}
}
Excessive activation of blood coagulation and neutrophil accumulation have been described in several human cancers. However, whether hypercoagulation and neutrophilia are linked and involved in cancer development is currently unknown. Here we show that spontaneous intestinal tumorigenesis correlates with the accumulation of low-density neutrophils with a pro-tumorigenic N2 phenotype and unprompted neutrophil extracellular traps (NET) formation. We find that increased circulating… CONTINUE READING
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management and short-term prognosis

  • Schulman, S. et al. Recurrent venous thromboembolism in anticoa cancer
  • J. Thromb. Haemost. 13, 1010–1018
  • 2015

A novel approach to assess the spontaneous gastrointestinal bleeding risk of antithrombotic agents using Apc(min/þ ) mice

  • H Wei
  • Thromb. Haemost
  • 2014

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