Coagulation in the mesangial area promotes ECM accumulation through factor V expression in MsPGN in rats.

@article{Liu2004CoagulationIT,
  title={Coagulation in the mesangial area promotes ECM accumulation through factor V expression in MsPGN in rats.},
  author={Ning Liu and Toshiaki Makino and Fumiaki Nogaki and Hitoshi Kusano and Katsuo Suyama and Eri Muso and Gisho Honda and Toru Kita and Takahiko Ono},
  journal={American journal of physiology. Renal physiology},
  year={2004},
  volume={287 4},
  pages={F612-20}
}
It is well known that tissue factor starts the extrinsic coagulation pathway, which activates factor X to Xa, and factor V is a membrane-bound potent cofactor for the terminating stage of prothrombin activation by factor Xa. In a previous in vitro study, factor V was induced in cultured mesangial cells by inflammatory stimulation and increased expression of factor V promoted fibrin generation on the cultured mesangial cell surface. We report that extracellular matrix (ECM) accumulation is… CONTINUE READING

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