Coagulation in severe sepsis: a central role for thrombomodulin and activated protein C.

@article{Faust2001CoagulationIS,
  title={Coagulation in severe sepsis: a central role for thrombomodulin and activated protein C.},
  author={Saul N Faust and Robert S Heyderman and Michael Levin},
  journal={Critical care medicine},
  year={2001},
  volume={29 7 Suppl},
  pages={S62-7; discussion S67-8}
}
OBJECTIVES To review the mechanisms that cause coagulation abnormalities in sepsis, focusing on the interaction between the vascular endothelium and the circulating coagulation factors, particularly the role of the protein C pathway and thrombomodulin. DATA SOURCES/STUDY SELECTION Published research abstracts and review articles on the experimental and clinical investigation of the pathophysiology of disseminated intravascular coagulation in sepsis. DATA EXTRACTION AND SYNTHESIS The data… CONTINUE READING

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