Coagulation in sepsis: all bugs bite equally

@article{Levi2004CoagulationIS,
  title={Coagulation in sepsis: all bugs bite equally},
  author={Marcel M. Levi and Tom van der Poll},
  journal={Critical Care},
  year={2004},
  volume={8},
  pages={99 - 100}
}
Sepsis almost invariably leads to hemostatic abnormalities, ranging from insignificant laboratory changes to severe disseminated intravascular coagulation. There is compelling evidence from clinical and experimental studies that disseminated intravascular coagulation is involved in the pathogenesis of microvascular dysfunction and contributes to organ failure. Data from the PROWESS phase III clinical trial of recombinant activated protein C in patients with severe sepsis confirm this notion and… CONTINUE READING

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