Coagulation in sepsis: all bugs bite equally

  title={Coagulation in sepsis: all bugs bite equally},
  author={Marcel M. Levi and Tom van der Poll},
  journal={Critical Care},
  pages={99 - 100}
Sepsis almost invariably leads to hemostatic abnormalities, ranging from insignificant laboratory changes to severe disseminated intravascular coagulation. There is compelling evidence from clinical and experimental studies that disseminated intravascular coagulation is involved in the pathogenesis of microvascular dysfunction and contributes to organ failure. Data from the PROWESS phase III clinical trial of recombinant activated protein C in patients with severe sepsis confirm this notion and… CONTINUE READING


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Publications referenced by this paper.
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Systemic host responses in severe sepsis analyzed by causative microorganism and treatment effects of drotrecogin alfa (activated).

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America • 2003
View 1 Excerpt

Recombinant human activated protein C (Xigris).

International journal of clinical practice • 2002
View 1 Excerpt

The role of cytokines in activation of coagulation and fibrinolysis in dengue shock syndrome

C Suharti, EC van Gorp, +5 authors JW van der Meer
Thromb Haemost • 2002
View 1 Excerpt

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