Coagulation in arthropods: defence, wound closure and healing.

@article{Theopold2004CoagulationIA,
  title={Coagulation in arthropods: defence, wound closure and healing.},
  author={U. Theopold and O. Schmidt and K. Söderhäll and M. Dushay},
  journal={Trends in immunology},
  year={2004},
  volume={25 6},
  pages={
          289-94
        }
}
Arthropods have open circulatory systems and must seal wounds and keep bacteria from entering the hemocoel using efficient clotting systems. Enzymes that crosslink the clot include transglutaminase, which is phylogenetically conserved, and phenoloxidase, which is not found in vertebrates. Prophenoloxidase is usually activated through a proteolytic cascade similar to the vertebrate clotting cascade. The well-characterized clotting cascade in horseshoe crabs is strongly activated by bacterial… Expand
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