Coagulation factors VII and X induce Ca2+ oscillations in Madin-Darby canine kidney cells only when proteolytically active.

@article{Camerer1996CoagulationFV,
  title={Coagulation factors VII and X induce Ca2+ oscillations in Madin-Darby canine kidney cells only when proteolytically active.},
  author={Eric Camerer and John Arne Rottingen and Jens Gustav Iversen and Hans Prydz},
  journal={The Journal of biological chemistry},
  year={1996},
  volume={271 46},
  pages={29034-42}
}
We have recently reported that the activated serine protease and blood coagulation Factor VII (FVIIa) can induce Ca2+ oscillations in Madin-Darby canine kidney cells. We now demonstrate a similar response by Madin-Darby canine kidney cells to the active coagulation Factor X (FXa), which is also a serine protease and a substrate of the tissue factor (TF).FVIIa complex in the initiation of the coagulation cascade. The phosphatidyl inositol-specific phospholipase C inhibitor U73122 inhibited the… CONTINUE READING