Coagulation factor XIII VaI34Leu polymorphism in patients with small vessel disease or primary intracerebral hemorrhage.


BACKGROUND AND PURPOSE Factor (F) XIII is a transglutaminase which stabilizes fibrin clots by forming cross-links between chains of fibrin. A common Val34Leu polymorphism of FXIII is correlated with the level of activated plasma FXIII. The homozygous 34Val genotype may be associated with an increased risk for thrombosis by forming fibrin fibers more… (More)


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