Coagulation factor X shields adenovirus type 5 from attack by natural antibodies and complement

@article{Xu2013CoagulationFX,
  title={Coagulation factor X shields adenovirus type 5 from attack by natural antibodies and complement},
  author={Zhili Xu and Qi Qiu and Jie Tian and Jeffrey S Smith and Gina M Conenello and Takashi Morita and Andrew P Byrnes},
  journal={Nature Medicine},
  year={2013},
  volume={19},
  pages={452-457}
}
Adenovirus type 5 (Ad5) specifically binds coagulation factor X (FX), and FX is normally essential for intravenously injected Ad5 vectors to transduce the liver. We demonstrate that the ability of FX to enhance liver transduction by Ad5 vectors is due to an unexpected ability of FX to protect Ad5 from attack by the classical complement pathway. In vitro, naive mouse serum neutralized Ad5 when FX was blocked from binding Ad5. This neutralization was mediated by natural IgM and the classical… CONTINUE READING
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