Coagulation factor Va binds to human umbilical vein endothelial cells and accelerates protein C activation.

@article{Maruyama1984CoagulationFV,
  title={Coagulation factor Va binds to human umbilical vein endothelial cells and accelerates protein C activation.},
  author={Ikuro Maruyama and Hatem H. Salem and P W Majerus},
  journal={The Journal of clinical investigation},
  year={1984},
  volume={74 1},
  pages={224-30}
}
In vitro the rate of protein C activation by thrombin is significantly accelerated by two distinct cofactors (a) the endothelial cell surface protein, thrombomodulin, and (b) human coagulation Factor Va. We have recently reported that the activity of Factor Va is contained in the 78,000-D light chain. In this study we have investigated the effects of Factor Va and its light chain on the activation of protein C in the presence of cultured endothelial cells. Thrombin-catalyzed protein C… CONTINUE READING

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