Coagulation activation following estrogen administration to postmenopausal women.

  title={Coagulation activation following estrogen administration to postmenopausal women.},
  author={Y G Caine and Kenneth A. Bauer and Samad Barzegar and Hugo Ten Cate and Frank M. Sacks and Brian W. Walsh and Isaac Schiff and Robert Rosenberg},
  journal={Thrombosis and haemostasis},
  volume={68 4},
We investigated coagulation system activation following estrogen treatment in 29 healthy postmenopausal women. Study participants received conjugated estrogens at 0.625 and 1.25 mg per day, and placebo for 3-month periods in a randomized crossover protocol. Blood samples were obtained on two consecutive days at the end of each treatment period for immunoassays of F1+2 and fibrinopeptide A (FPA), markers of factor Xa action on prothrombin and thrombin action on fibrinogen in vivo, respectively… CONTINUE READING


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