Coagulation, inflammation, and apoptosis: different roles for protein S and the protein S-C4b binding protein complex.

  title={Coagulation, inflammation, and apoptosis: different roles for protein S and the protein S-C4b binding protein complex.},
  author={Suely Meireles Rezende and R. Simmonds and David A. Lane},
  volume={103 4},
Protein S (PS) has an established role as an important cofactor to activated protein C (APC) in the degradation of coagulation cofactors Va and VIIIa. This anticoagulant role is evident from the consequences of its deficiency, when there is an increased risk of venous thromboembolism. In human plasma, PS circulates approximately 40% as free PS (FPS) and 60% in complex with C4b-binding protein (C4BP). Formation of this complex results in loss of PS cofactor function, and C4BP can then modulate… 

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