Coadministration of thiazides increases the efficacy of loop diuretics even in patients with advanced renal failure.

@article{Fliser1994CoadministrationOT,
  title={Coadministration of thiazides increases the efficacy of loop diuretics even in patients with advanced renal failure.},
  author={Danilo Fliser and Manuela Schroeter and M. Neubeck and Eberhard Ritz},
  journal={Kidney international},
  year={1994},
  volume={46 2},
  pages={
          482-8
        }
}
It is commonly assumed that thiazide diuretics are ineffective in patients with advanced renal failure (GFR < 30 ml/min/1.73 m2). Thiazides act on the nephron segment distal to the ascending thick loop of Henle, that is, the site of action of loop diuretics. Blockade of sodium reabsorption in the thiazide-sensitive segment should therefore obliterate the compensatory increase in sodium reabsorption seen after administration of loop diuretics and thus potentiate the natriuretic efficacy of loop… CONTINUE READING

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