Corpus ID: 9889114

Coadministration of nefazodone and desipramine: a pharmacokinetic interaction study.

@article{Khan2007CoadministrationON,
  title={Coadministration of nefazodone and desipramine: a pharmacokinetic interaction study.},
  author={Ahsan Y. Khan and S. Preskorn and W. D. Horst},
  journal={JPMA. The Journal of the Pakistan Medical Association},
  year={2007},
  volume={57 5},
  pages={
          230-5
        }
}
OBJECTIVE To determine the potential for pharmacokinetic interaction between nefazodone (NFZ), and desipramine (DMI). METHOD A single center, open-label, multiple-dose, parallel-group pharmacokinetic trial conducted in 28 healthy male and female subjects. Group A received DMI 50 mg/day for 2 days followed by DMI 75 mg/day for the next 17 days. On Days 10-14, subjects also received 100 mg NFZ twice daily, and during Days 15-19, the NFZ dose was increased to 150 mg twice daily. Group B received… Expand

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