Coadministration of intravenous nicotine and oral alcohol in rats

@article{L2009CoadministrationOI,
  title={Coadministration of intravenous nicotine and oral alcohol in rats},
  author={Anh Dzung L{\^e} and Steven Lo and Stephen Harding and Walter Juzytsch and Peter W. Marinelli and Douglas Funk},
  journal={Psychopharmacology},
  year={2009},
  volume={208},
  pages={475-486}
}
Alcohol and nicotine are the most commonly abused drugs, and they are often taken together. We have developed a procedure in which rats self-administer nicotine intravenously and alcohol orally during the same operant session. Male Wistar rats were trained to self-administer alcohol (12%, w/v; 0.19 ml/alcohol delivery) or implanted with jugular catheters and trained to self-administer nicotine (30 μg/kg i.v./infusion) by pressing a lever or were trained to self-administer both drugs, some with… CONTINUE READING
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