Coadministration of interleukins 7 and 15 with bacille Calmette-Guérin mounts enduring T cell memory response against Mycobacterium tuberculosis.

@article{Singh2010CoadministrationOI,
  title={Coadministration of interleukins 7 and 15 with bacille Calmette-Gu{\'e}rin mounts enduring T cell memory response against Mycobacterium tuberculosis.},
  author={Vijender Singh and Uthaman Gowthaman and Shweta Jain and Pankaj Parihar and Sunil Banskar and Pushpa L. Gupta and Umesh Dutt Gupta and Javed Naim Agrewala},
  journal={The Journal of infectious diseases},
  year={2010},
  volume={202 3},
  pages={480-9}
}
BACKGROUND The bacille Calmette-Guérin (BCG) vaccine renders protection against tuberculosis in childhood but not in adulthood. This may be due to its failure to induce long-lasting memory T cells. T cell memory is dependent on crucial cytokine signals during the priming phases. Therefore, coadministering the BCG vaccine with cytokines may improve its efficacy. METHODS A combination of the cytokines interleukin 7 (IL-7) and interleukin 15 (IL-15) or a combination of the cytokines interleukin… CONTINUE READING

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